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Article

Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase.

Nature chemical biology - 1 Dec 2017

Hu Chia-Wei, Worth Matthew, Fan Dacheng, Li Baobin, Li Hao, Lu Lei, Zhong Xiaofang, Lin Ziqing, Wei Liming, Ge Ying, Li Lingjun, Jiang Jiaoyang

Abstract excerpt

O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is an essential human glycosyltransferase that adds O-GlcNAc modifications to numerous proteins. However, little is known about the mechanism with which OGT recognizes various protein substrates. Here we report on GlcNAc electrophilic probes (GEPs) to expedite the characterization of OGT-substrate recognition. Data from mass spectrometry, X-ray...

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Identifiers

PMID: 29058723
DOI: 10.1038/nchembio.2494
PMCID: PMC5698155

Genes

OGT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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