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Article

Characterisation of CMP-sialic acid transporter substrate recognition.

Chembiochem : a European journal of chemical biology - 11 Oct 2013

Maggioni Andrea, von Itzstein Mark, Rodríguez Guzmán Ingrid Bibiana, Ashikov Angel, Stephens Alexandre S, Haselhorst Thomas, Tiralongo Joe

Abstract excerpt

CMP-sialic acid transporter: We report an in-depth, multidisciplinary, structural study that has identified the amino acid residues intimately involved in CMP-sialic acid transporter (CST) substrate specificity. Our data provide a significant contribution towards a better understanding the structure-function relationship of this important family of transporters and the rational design of CST inhibitors.

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PMID: 24014346
DOI: 10.1002/cbic.201300298

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