Article
Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis.
The EMBO journal - 5 Apr 2006
Rao Francesco V, Dorfmueller Helge C, Villa Fabrizio, Allwood Matthew, Eggleston Ian M, van Aalten Daan M F
Abstract excerpt
O-linked N-acetylglucosamine (O-GlcNAc) modification of specific serines/threonines on intracellular proteins in higher eukaryotes has been shown to directly regulate important processes such as the cell cycle, insulin sensitivity and transcription. The structure, molecular mechanisms of catalysis, protein substrate recognition/specificity of the eukaryotic O-GlcNAc transferase and hydrolase are largely unknown....
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