Article

Ancestral protein reconstruction reveals the mechanism of substrate specificity in FN3K-mediated deglycation

2025-09-22

Abstract excerpt

<title>Abstract</title> <p>Protein glycation is a detrimental byproduct of carbohydrate metabolism, and nearly all organisms encode kinases that facilitate the removal of early glycation products. In humans, these repair functions are performed by Fructosamine-3 and Ketosamine-3 kinases (FN3K, KT3K). Recent structural studies identified conserved residues essential for FN3K activity, but the molecular basis for s...

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Literature Corpus work: ae3cf29b-227f-5e58-a3a5-13031c8b66b7
DOI: 10.21203/rs.3.rs-7263937/v1

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