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Discovery and Development of Promiscuous O-Glycan Hydrolases for Removal of Intact Sialyl T-Antigen.

ACS chemical biology - 15 Oct 2021

Wardman Jacob F, Rahfeld Peter, Liu Feng, Morgan-Lang Connor, Sim Lyann, Hallam Steven J, Withers Stephen G

Abstract excerpt

Mucin-type O-glycosylation (O-glycosylation) is a common post-translational modification that confers distinct biophysical properties to proteins and plays crucial roles in intercellular signaling. Yet, despite the importance of O-glycans, relatively few tools exist for their analysis and modification. In particular, there is a need for enzymes that can cleave the wide range of O-glycan structures found on...

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PMID: 34309358
DOI: 10.1021/acschembio.1c00316

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