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Article

Mutational analysis of the catalytic domain of O-linked N-acetylglucosaminyl transferase.

The Journal of biological chemistry - 21 Oct 2005

Lazarus Brooke D, Roos Mark D, Hanover John A

Abstract excerpt

O-Linked N-acetylglucosaminyltransferase (OGT) catalyzes the transfer of O-linked GlcNAc to serine/threonine residues of a variety of target proteins, many of which have been implicated in such diseases as diabetes and neurodegeneration. The addition of O-GlcNAc to proteins occurs in response to fluctuations in cellular concentrations of UDP-GlcNAc, which result from nutrients entering the hexosamine biosynthetic...

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Source

Identifiers

PMID: 16105839
DOI: 10.1074/jbc.M504948200

Genes

OGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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