Article

Phage display uncovers a sequence motif that drives polypeptide binding to a conserved regulatory exosite of O-GlcNAc transferase

2023-03-16

Abstract excerpt

<h4>ABSTRACT</h4> The modification of nucleocytoplasmic proteins by O-linked N-acetylglucosamine ( O -GlcNAc) is an important regulator of cell physiology. O -GlcNAc is installed on over a thousand proteins by just one enzyme, O -GlcNAc transferase (OGT). How OGT is therefore regulated is therefore a topic of interest. To gain insight into these questions, we used OGT to perform phage display selection from an...

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Literature Corpus work: 2e2e10b9-70c6-5072-b177-6fb472af71ae
DOI: 10.1101/2023.03.15.532872

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