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TDP-43 dysregulation impairs cholesterol metabolism linked with myelination defects

4 Sept 2025

Abstract excerpt

Abstract TDP-43 is a nuclear protein encoded by the TARDBP gene, which forms pathological aggregates in various neurodegenerative diseases, collectively known as TDP-43 proteinopathies, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). These diseases are characterized by multiple pathological mechanisms, with disruptions in lipid regulatory pathways emerging as a critical factor....

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PMID: 40906043
DOI: 10.1007/s00401-025-02927-x

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