Article

TDP-43 dysregulation impairs cholesterol metabolism linked with myelination defects

2025-04-01

Abstract excerpt

<title>Abstract</title> <p>TDP-43 is a nuclear protein encoded by the TARDBP gene, which forms pathological aggregates in various neurodegenerative diseases, collectively known as TDP-43 proteinopathies, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). These diseases are characterized by multiple pathological mechanisms, with disruptions in lipid regulatory pathways emerging as a c...

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Literature Corpus work: 5bf71ac1-0e30-5f4e-8c7c-03003d604310
DOI: 10.21203/rs.3.rs-6256163/v1

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