Article

ALS-Causing Protein TDP-43 Impairs SREBP2 Cholesterol Regulation

2021-06-21

Abstract excerpt

<title>Abstract</title> <p>Dyslipidemia is correlated with the prognosis of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disorder characterized pathologically by TAR DNA binding protein (TDP-43) inclusions. We investigated molecular mechanisms of lipid metabolism regulated by TDP-43 in ALS. Expression microarray and RNA deep sequencing (RNA-Seq) were performed using cell lines expressing doxycycline-...

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Literature Corpus work: 4e3eff47-e9d7-5520-8f87-0a60cd20be1a
DOI: 10.21203/rs.3.rs-608138/v1

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