Article

MiR-223 Enhances Lipophagy by Suppressing CTSB in Microglia Following Lysolecithin-Induced Demyelination in Mice

2024-02-12

Abstract excerpt

<h4>Background: </h4> Lipid droplet (LD)-laden microglia are key pathological hallmarks of multiple sclerosis. The recent discovery of a novel microglial subtype, lipid-droplet-accumulating microglia (LDAM), is notable for increased inflammatory factor secretion and diminished phagocytic capability. Lipophagy, the autophagy-mediated selective degradation of LDs, plays a critical role in this context. This study in...

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Literature Corpus work: 8d48dc15-299e-5e6c-a4d5-42e940ad5e02
DOI: 10.21203/rs.3.rs-3936707/v1

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