Article

Hypatia: Comparative Isoform Profiling Across Cell Populations from Long-Read Single-Cell Transcriptomes

2026-01-14

Abstract excerpt

High-throughput long-read single-cell RNA-sequencing enables isoform-level study across single cells, yet methods for systematically assessing cell-to-cell variations remain limited. Here, we develop Hypatia, a comprehensive platform for dissecting isoform complexities across cell populations, devising Tsallis entropy and Cramer’s V to facilitate robust comparative profiling. Hypatia revealed prominent isoform spe...

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Literature Corpus work: d0bf48cc-e5fa-5346-875d-b19c66a0b235
DOI: 10.64898/2026.01.13.699341

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