Article

Perplexity as a Metric for Isoform Diversity in the Human Transcriptome

2025-07-02

Abstract excerpt

Characterizing the extensive isoform diversity revealed by long-read RNA-sequencing remains challenging. After removal of technical artifacts, existing pipelines apply arbitrary expression thresholds that filter out bona fide transcript structures, misrepresenting diversity and hindering reproducibility. Instead of discarding isoforms, we propose a fundamentally distinct approach to quantifying isoform diversity u...

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Literature Corpus work: 5cabe881-8218-5348-bb03-8acc65cd7cd6
DOI: 10.1101/2025.07.02.662769

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