Article

Accurate isoform quantification by joint short- and long-read RNA-sequencing

2024-07-13

Abstract excerpt

Accurate quantification of transcript isoforms is crucial for understanding gene regulation, functional diversity, and cellular behavior. Existing RNA sequencing methods have significant limitations: short-read (SR) sequencing provides high depth but struggles with isoform deconvolution, whereas long-read (LR) sequencing offers isoform resolution at the cost of lower depth, higher noise, and technical biases. Addr...

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Literature Corpus work: 904ba6e6-bacc-5f8c-8dea-f4742b772a5c
DOI: 10.1101/2024.07.11.603067

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