Article

IsoformSwitchAnalyzeR v2: Analysis of Functional Isoform Changes in Long-read and Single-cell Sequencing Data

2025-12-11

Abstract excerpt

Alternative splicing enables a single gene to produce a variety of mRNA transcripts, significantly enhancing protein diversity in higher eukaryotes. Isoform switching refers to the differential usage of a gene’s transcripts and occurs pervasively across physiological and pathological conditions. IsoformSwitchAnalyzeR was developed to identify these isoform switches and analyze their functional consequences. Advanc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 986b0300-bdf2-569d-aebe-38d6d8d0c62a
DOI: 10.64898/2025.12.08.693027

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IsoformSwitchAnalyzeR v2: Analysis of Functional Isoform Changes in Long-read and Single-cell Sequencing DataDOI 10.64898/2025.12.08.693027Read

IsoformSwitchAnalyzeR: Analysis of changes in genome-wide patterns of alternative splicing and its functional consequencesSemantic proximity Read

Hypatia: Comparative Isoform Profiling Across Cell Populations from Long-Read Single-Cell TranscriptomesSemantic proximity Read

ScisorWiz: Visualizing Differential Isoform Expression in Single-Cell Long-Read DataSemantic proximity Read

SCOTCH: isoform-level characterization of gene expression through long-read single-cell RNA sequencingSemantic proximity Read

IFDlong: an isoform and fusion detector for accurate annotation and quantification of long-read RNA-seq dataSemantic proximity Read

Surveying the landscape of RNA isoform diversity and expression across 9 GTEx tissues using long-read sequencing dataSemantic proximity Read

SpliceDecoder: A High-Throughput Tool for Guiding the Functional Interpretation of Differential Splicing EventsSemantic proximity Read

Comprehensive characterization of single cell full-length isoforms in human and mouse with long-read sequencingSemantic proximity Read

Biosurfer for systematic tracking of regulatory mechanisms leading to protein isoform diversitySemantic proximity Read

<i>SpliceImpactR</i> maps alternative RNA processing events driving protein functional diversitySemantic proximity Read

Deciphering the Genetic Orchestra: Unveiling Splice Form Dynamics in Human Cell LinesSemantic proximity Read

Analyzing cell-type-specific isoform expression using IsoDiffR and long-read single-cell RNA sequencingSemantic proximity Read