Article

Accurate strand-specific long-read transcript isoform discovery and quantification at bulk, single-cell, and single-nucleus resolution

2026-02-12

Abstract excerpt

Recent advances in long-read transcriptome sequencing enable high-throughput profiling of full-length RNA isoforms in bulk, single-cell, and single-nucleus samples. However, long-read datasets typically contain a mixture of complete and partial transcripts, leading to pervasive ambiguity in read-to-isoform assignment and complicating accurate isoform identification and quantification, particularly in the absence o...

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Literature Corpus work: 97c67007-f3bc-5cf5-aa0e-7c73f726d638
DOI: 10.64898/2026.02.12.705617

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