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Article

The catalytic mechanism of the RNA methyltransferase METTL3

2023-09-06

Abstract excerpt

The complex of methyltransferase-like proteins 3 and 14 (METTL3-14) is the major enzyme that deposits N 6 -methyladenosine (m 6 A) modifications on mRNA in humans. METTL3-14 plays key roles in various biological processes through its methyltransferase (MTase) activity. However, little is known about its substrate recognition and methyl transfer mechanism from its cofactor and methyl donor S-adenosylmethionine (S...

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Literature Corpus work
d0578adf-c00b-5c54-adb6-6c1e8cae26b0
DOI
10.1101/2023.09.06.556513
Open publication

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The catalytic mechanism of the RNA methyltransferase METTL3DOI 10.1101/2023.09.06.556513
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