Article

Structure of METTL3-METTL14 with an m6A nucleotide reveals insights into m6A conversion and sensing

2024-10-23

Abstract excerpt

<title>Abstract</title> <p> The nuclear METTL3-METTL14 transfers a methyl group from SAM to convert the <italic>N</italic> <sup> <italic>6</italic> </sup> of adenosine (A) in RNA to m <sup>6</sup> A and in ssDNA to 6mA. m <sup>6</sup> A marks are prevalent in eukaryotic mRNAs and lncRNAs and modulate their stability and fate in a context-dependent manner. The cytoplasmic METTL3 can act as a m <sup>6</s...

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Literature Corpus work: a58880d0-5488-54de-809b-d380716a4e41
DOI: 10.21203/rs.3.rs-3150186/v2

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