Article

Identification of potential natural compound inhibitors and drug like molecules against human METTL3 by docking and molecular dynamics simulation

2022-06-20

Abstract excerpt

Nucleotide level chemical modification in transcriptome is critical in regulating different cellular processes, including cancer. The most investigated epitranscriptomic modification is methylation at the N 6 -position of adenosine (m 6 A). This dynamic modification process is carried out by: writer, reader and eraser proteins. Writers are methyltransferases, METTL3 is the major writer that works in association...

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Literature Corpus work: fca8378e-2ce4-5f47-a379-80412eebf4d9
DOI: 10.1101/2022.06.19.496750

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