Article

A computational design strategy for discovering the protein targets of histone lysine methyltransferases

2018-01-01

Abstract excerpt

The activity of lysine methyltransferases (KMTs) is crucial for the regulation of chromatin-related processes, such as gene expression. Since all KMTs catalyse the transfer of a methyl group from the same SAM cofactor, no current technology is able to directly assess which KMT has performed each observed methylation in a cellular context. This information would be particularly informative in the development of mor...

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Literature Corpus work: 9fa5a54b-465b-5961-a15a-9ae0c2a25911
DOI: 10.25560/68037

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