Article

Molecular basis of tRNA modification by the human m <sup>5</sup> C methyltransferase NSUN2

2026-03-18

Abstract excerpt

<h4>ABSTRACT</h4> RNA 5-methylcytidine (m 5 C) is a prevalent modification that drives RNA stability and function. In humans, m 5 C is deposited on distinct RNA substrates by DNMT2/TRDMT1 and the NSUN family, to regulate diverse cellular processes, but how m 5 C writers recognise their substrates remains unclear. NSUN2 is a major m 5 C methyltransferase with broad roles in cell physiology and strong links to...

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Literature Corpus work: 6d443019-2c57-5268-84ee-217b9e15a1d2
DOI: 10.64898/2026.03.16.712100

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