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The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112

12 Jul 2019

Abstract excerpt

N6-methyladenosine (m6A) has recently been found abundantly on messenger RNA and shown to regulate most steps of mRNA metabolism. Several important m6A methyltransferases have been described functionally and structurally, but the enzymes responsible for installing one m6A residue on each subunit of human ribosomes at functionally important sites have eluded identification for over 30 years. Here, we identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31328227
DOI: 10.1093/nar/gkz619

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The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112PMID 31328227Read ↗

The METTL5-TRMT112 <i> N <sup>6</sup> </i> -methyladenosine methyltransferase complex regulates metabolism and development via translationSemantic proximity Read ↗

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Human TRMT2A methylates tRNA and contributes to translation fidelitySemantic proximity Read ↗

The human mitochondrial 12S rRNA m <sup>4</sup> C methyltransferase METTL15 is required for proper mitochondrial functionSemantic proximity Read ↗

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TRMT2B is responsible for both tRNA and rRNA m <sup>5</sup> U-methylation in human mitochondriaSemantic proximity Read ↗

Mutations in m6A consensus motifs are suppressed in the m6A modified genes in human cancer cells.Semantic proximity Read ↗

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Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAsSemantic proximity Read ↗

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