Article

Pseudohypoxia-stabilized HIF2⍺ transcriptionally inhibits MNRR1, a druggable target in MELAS

2024-10-08

Abstract excerpt

<h4> Abstract </h4> The observation that amounts of the mitochondrial regulator MNRR1 (CHCHD2, AAG10, PARK22) are reduced in several pathologies, and that restoration of its level normalizes the pathological phenotype, prompted a search for compounds that could increase MNRR1 levels. High throughput screening of a 2400-compound drug and natural products library uncovered the antifungal drug nitazoxanide and its...

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Literature Corpus work: d025e692-3f4e-5c7e-97ea-caf1db409ffe
DOI: 10.1101/2024.10.07.617011

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