Article

Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production

2023-10-18

Abstract excerpt

Respiratory chain dysfunction can decrease ATP and increase reactive oxygen species (ROS) levels. Despite the importance of these metabolic parameters to a wide range of cellular functions and disease, we lack an integrated understanding of how they are differentially regulated. To address this question, we adapted a CRISPRi- and FACS-based platform to compare the effects of respiratory gene knockdown on ROS to th...

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Literature Corpus work: 27a1d152-4aed-5933-96fa-6bda3f257fb2
DOI: 10.1101/2023.10.14.562276

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