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Article

Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.

Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 2020

Aras Siddhesh, Purandare Neeraja, Gladyck Stephanie, Somayajulu-Nitu Mallika, Zhang Kezhong, Wallace Douglas C, Grossman Lawrence I

Abstract excerpt

MNRR1 (CHCHD2) is a bi-organellar regulator of mitochondrial function that directly activates cytochrome c oxidase in the mitochondria and functions in the nucleus as a transcriptional activator for hundreds of genes. Since MNRR1 depletion contains features of a mitochondrial disease phenotype, we evaluated the effects of forced expression of MNRR1 on the mitochondrial disease MELAS (mitochondrial...

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Identifiers

PMID: 33257573
DOI: 10.1073/pnas.2005877117
PMCID: PMC7749287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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