Article

Imetelstat-Mediated Alterations in Fatty Acid Metabolism To Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid Leukemia

2023-04-28

Abstract excerpt

<h4>ABSTRACT</h4> Telomerase enables replicative immortality in most cancers including acute myeloid leukemia (AML). Imetelstat is a first-in-class telomerase inhibitor with clinical efficacy in myelofibrosis and myelodysplastic syndromes. Here, we develop an AML patient-derived xenograft (PDX) resource, and perform integrated genomics, transcriptomics, and lipidomics analyses combined with functional genetics to...

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Literature Corpus work: 55b778d3-bc24-50f1-81ea-dee3330b34af
DOI: 10.1101/2023.04.25.538357

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