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Article

Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death.

Nature communications - 1 Jun 2020

Balsa Eduardo, Perry Elizabeth A, Bennett Christopher F, Jedrychowski Mark, Gygi Steven P, Doench John G, Puigserver Pere

Abstract excerpt

Electron transport chain (ETC) defects occurring from mitochondrial disease mutations compromise ATP synthesis and render cells vulnerable to nutrient and oxidative stress conditions. This bioenergetic failure is thought to underlie pathologies associated with mitochondrial diseases. However, the precise metabolic processes resulting from a defective mitochondrial ETC that compromise cell viability under stress...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32483148
DOI: 10.1038/s41467-020-16423-1
PMCID: PMC7264245

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