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Article

Preserving mitochondria to treat hypertrophic cardiomyopathy: From rare mitochondrial DNA mutation to heart failure therapy?

The Journal of clinical investigation - 17 Jul 2023

Diwan Abhinav

Abstract excerpt

Hypertrophic cardiomyopathy and pathological cardiac hypertrophy are characterized by mitochondrial structural and functional abnormalities. In this issue of the JCI, Zhuang et al. discovered 1-deoxynojirimycin (DNJ) through a screen of mitochondrially targeted compounds. The authors described the effects of DNJ in restoring mitochondria and preventing cardiac myocyte hypertrophy in cellular models carrying a...

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Identifiers

PMID: 37463442
DOI: 10.1172/JCI171965
PMCID: PMC10348762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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