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Article

Hypoxia as a therapy for mitochondrial disease

25 Feb 2016

Abstract excerpt

Defects in the mitochondrial respiratory chain (RC) underlie a spectrum of human conditions, ranging from devastating inborn errors of metabolism to aging. We performed a genome-wide Cas9-mediated screen to identify factors that are protective during RC inhibition. Our results highlight the hypoxia response, an endogenous program evolved to adapt to limited oxygen availability. Genetic or small-molecule...

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PMID: 26917594
DOI: 10.1126/science.aad9642

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