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Article

Identification of MYC synthetic lethal genes and networks

2024-04-25

Abstract excerpt

<h4>SUMMARY</h4> MYC is a potent oncogene that is frequently overexpressed in human tumors arising in different tissues. To date there are no approved therapies to directly antagonize oncogenic MYC and its role in driving tumorigenesis. As an alternative approach we employed genetic screens using CRISPR and shRNA to identify the genes that are required for the survival and growth of cells harboring high levels of...

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Literature Corpus work
f5276045-5511-51d1-b407-8aa6ea6aee70
DOI
10.1101/2024.04.25.590465
Open publication

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Identification of MYC synthetic lethal genes and networksDOI 10.1101/2024.04.25.590465
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