Article

A Practical Approach for Targeting Structural Variants Genome-wide in Plasma Cell-free DNA

2023-10-27

Abstract excerpt

Interrogating gene mutations and aberrant DNA methylation in plasma cell-free DNA (cfDNA) has become increasingly common for monitoring tumor burden in cancer patients. However, no tests currently target chromosomal structural variants (SVs) genome-wide. Here, we report a simple molecular and sequencing workflow, Genome-wide Analysis of Palindrome Formation (GAPF-seq), to probe DNA palindromes, a type of SV that o...

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Literature Corpus work: 11dac83b-470a-5203-b87c-f6e8a3e19c04
DOI: 10.1101/2023.10.25.564058

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