Article

Optimizing clinical genomic analysis of FFPE specimens for enhanced data quality, reduced artefacts, and ensured reliability

2024-06-13

Abstract excerpt

<title>Abstract</title> <p>Formalin-Fixed Paraffin-Embedded (FFPE) samples are routinely used for genome sequencing as companion diagnostics for targeted therapies for cancer patients. While targeted sequencing of FFPE tissue usually provides accurate assessment of hotspot mutations, whole exome or genome sequencing data are loaded with artefacts. Standardized and optimized methods are needed to overcome these ob...

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Literature Corpus work: f3a89d5f-738a-54a6-9e25-741d4e7c71c4
DOI: 10.21203/rs.3.rs-4481817/v1

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