Article
Integrative detection and analysis of structural variation in cancer genomes.
Nature genetics - 1 Oct 2018
Dixon Jesse R, Xu Jie, Dileep Vishnu, Zhan Ye, Song Fan, Le Victoria T, Yardımcı Galip Gürkan, Chakraborty Abhijit, Bann Darrin V, Wang Yanli, Clark Royden, Zhang Lijun, Yang Hongbo, Liu Tingting, Iyyanki Sriranga, An Lin, Pool Christopher, Sasaki Takayo, Rivera-Mulia Juan Carlos, Ozadam Hakan, Lajoie Bryan R, Kaul Rajinder, Buckley Michael, Lee Kristen, Diegel Morgan, Pezic Dubravka, Ernst Christina, Hadjur Suzana, Odom Duncan T, Stamatoyannopoulos John A, Broach James R, Hardison Ross C, Ay Ferhat, Noble William Stafford, Dekker Job, Gilbert David M, Yue Feng
Abstract excerpt
Structural variants (SVs) can contribute to oncogenesis through a variety of mechanisms. Despite their importance, the identification of SVs in cancer genomes remains challenging. Here, we present a framework that integrates optical mapping, high-throughput chromosome conformation capture (Hi-C), and whole-genome sequencing to systematically detect SVs in a variety of normal or cancer samples and cell lines. We...
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