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Identification of Somatic Structural Variants in Solid Tumors By Optical Genome Mapping

2021-02-09

Abstract excerpt

Genomic structural variants comprise a significant fraction of somatic mutations driving cancer onset and progression. However, such variants are not readily revealed by standard next generation sequencing. Optical genome mapping (OGM) surpasses short read sequencing in detecting large (>500bp) and complex structural variants (SVs) but requires isolation of ultra-high molecular weight DNA from the tissue of intere...

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Literature Corpus work
335667f6-ee5c-5dd5-9ec3-021da414f1e2
DOI
10.1101/2021.02.04.21250683
Open publication

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Identification of Somatic Structural Variants in Solid Tumors By Optical Genome MappingDOI 10.1101/2021.02.04.21250683
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