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Article

Evaluating the repair of DNA derived from formalin-fixed paraffin-embedded tissues prior to genomic profiling by SNP-CGH analysis.

Laboratory investigation; a journal of technical methods and pathology - 1 Jun 2013

Hosein Abdel Nasser, Song Sarah, McCart Reed Amy E, Jayanthan Janani, Reid Lynne E, Kutasovic Jamie R, Cummings Margaret C, Waddell Nic, Lakhani Sunil R, Chenevix-Trench Georgia, Simpson Peter T

Abstract excerpt

Pathology archives contain vast resources of clinical material in the form of formalin-fixed paraffin-embedded (FFPE) tissue samples. Owing to the methods of tissue fixation and storage, the integrity of DNA and RNA available from FFPE tissue is compromized, which means obtaining informative data regarding epigenetic, genomic, and expression alterations can be challenging. Here, we have investigated the utility...

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Identifiers

PMID: 23568031
DOI: 10.1038/labinvest.2013.54

Genes

EGFR
ERBB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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