Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational profiling of micro-dissected pre-malignant lesions from archived specimens.

BMC medical genomics - 18 Nov 2020

Nachmanson Daniela, Steward Joseph, Yao Huazhen, Officer Adam, Jeong Eliza, O'Keefe Thomas J, Hasteh Farnaz, Jepsen Kristen, Hirst Gillian L, Esserman Laura J, Borowsky Alexander D, Harismendy Olivier

Abstract excerpt

BACKGROUND: Systematic cancer screening has led to the increased detection of pre-malignant lesions (PMLs). The absence of reliable prognostic markers has led mostly to over treatment resulting in potentially unnecessary stress, or insufficient treatment and avoidable progression. Importantly, most mutational profiling studies have relied on PML synchronous to invasive cancer, or performed in patients without...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benchmarking
Share to Carcinoma, Intraductal, Noninfiltrating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dissection

Share to DNA Fragmentation

Share to Genes, erbB-2

Share to Paraffin Embedding

Share to Specimen Handling

Share to Tissue Fixation

Source

Open in PubMed Open full text

Identifiers

PMID: 33208147
DOI: 10.1186/s12920-020-00820-y
PMCID: PMC7672910

Genes

PML
ERBB2
FGFR1
GATA3
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational profiling of micro-dissected pre-malignant lesions from archived specimens.PMID 33208147Read ↗

Mutational profiling of micro-dissected pre-malignant lesions from archived specimensSemantic proximity Read ↗

Liquid Biopsies beyond Mutation Calling: Genomic and Epigenomic Features of Cell-Free DNA in CancerSemantic proximity Read ↗

High-throughput detection of clinically relevant mutations in archived tumor samples by multiplexed PCR and next-generation sequencing.Semantic proximity Read ↗

Large-scale analysis of whole genome sequencing data from formalin-fixed paraffin-embedded cancer specimens demonstrates preservation of clinical utility.Semantic proximity Read ↗

FFPE breast tumour blocks provide reliable sources of both germline and malignant DNA for investigation of genetic determinants of individual tumour responses to treatment.Semantic proximity Read ↗

Maximizing the clinical utility and performance of cytology samples for comprehensive genetic profiling – A report on the impact of process optimization through the analysis of 4,871 cytology samples profiled by MSK-IMPACTSemantic proximity Read ↗

Comparative Lesions Analysis Through a Targeted Sequencing Approach.Semantic proximity Read ↗

Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing.Semantic proximity Read ↗

Validation and Application of a Custom-Designed Targeted Next-Generation Sequencing Panel for the Diagnostic Mutational Profiling of Solid Tumors.Semantic proximity Read ↗

Genome-scale mutational signature analysis in archived fixed tissues.Semantic proximity Read ↗

Development of a novel NGS methodology for ultrasensitive circulating tumour DNA detection as a tool for early-stage breast cancer diagnosisSemantic proximity Read ↗

Identification of high-confidence somatic mutations in whole genome sequence of formalin-fixed breast cancer specimens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.