Article

Unraveling cfDNA Fragmentation Patterns: Linking Chromatin Architecture to Cancer Diagnostic Sensitivity

2024-11-18

Abstract excerpt

<h4>Summary</h4> Circulating cell-free DNA (cfDNA) liquid biopsies offer a powerful, non-invasive approach for cancer diagnostics, leveraging DNA fragments primarily released during apoptosis. Using droplet digital PCR on cfDNA samples from 88 breast and colorectal cancer patients, we uncovered highly consistent nucleosome breakpoints across individuals. Proximity to these cfDNA breakpoints diminishes the sensiti...

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Literature Corpus work: 31340431-a0fc-5f18-90fc-023fae728e44
DOI: 10.1101/2024.11.16.623159

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