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Robust detection of translocations in lymphoma FFPE samples using targeted locus capture-based sequencing

7 Jun 2021

Abstract excerpt

In routine diagnostic pathology, cancer biopsies are preserved by formalin-fixed, paraffin-embedding (FFPE) procedures for examination of (intra-) cellular morphology. Such procedures inadvertently induce DNA fragmentation, which compromises sequencing-based analyses of chromosomal rearrangements. Yet, rearrangements drive many types of hematolymphoid malignancies and solid tumors, and their manifestation is...

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PMID: 34099699
DOI: 10.1038/s41467-021-23695-8

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