Article

PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infection

2024-08-27

Abstract excerpt

<title>Abstract</title> Parkinson’s disease (PD) is characterized by a protracted period of non-motor symptoms, including gastrointestinal (GI) dysfunction, which can precede the development of the cardinal motor deficits by decades. This long prodrome of disease is highly suggestive of immune cell involvement in the initiation of disease, but currently the field lacks robust model systems to study such mechan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e356b68e-38e6-5e51-b8f9-d8994379dbd2
DOI: 10.21203/rs.3.rs-4747651/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infectionDOI 10.21203/rs.3.rs-4747651/v1Read

PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infectionSemantic proximity Read

A single Citrobacter rodentium infection in Pink1 knockout and wildtype mice leads to regional blood-brain-barrier perturbation and limited microglial activation without dopamine neuron axon terminal lossSemantic proximity Read

Modeling gene-environment interactions in Parkinson’s Disease: Helicobacter pylori infection of Pink1 −/− mice induces CD8 T cell-dependent motor and cognitive dysfunctionSemantic proximity Read

The Role of Immune Dysfunction in Parkinson's Disease DevelopmentSemantic proximity Read

Identification of immune-mitophagy related gene in PD based on single-cell sequencing and Mendelian randomizationSemantic proximity Read

Gut-brain axis neurodegeneration in a Drosophila model of Parkinson’s disease is linked to mitochondrial dysfunctionSemantic proximity Read

LRRK2-G2019S Synergizes with Ageing and Low-Grade Inflammation to Promote Gut and Peripheral Immune Cell Activation that Precede Nigrostriatal DegenerationSemantic proximity Read

Bidirectional disruption of Lrrk2 function drives T cell dysregulation and an exhaustion-like immune responseSemantic proximity Read

Regulatory Role of DDX17 in Immune-Autophagy Pathways of Parkinson’s Disease Revealed by Single-Cell and Genetic AnalysesSemantic proximity Read

Mapping the peripheral immune landscape of Parkinson’s disease patients with single-cell sequencingSemantic proximity Read

LRRK2-G2019S Synergizes With Ageing and Low-Grade Inflammation to Promote Gut and Peripheral Immune Cell Activation That Precede Nigrostriatal DegenerationSemantic proximity Read

LRRK2 regulates the activation of the unfolded protein response and antigen presentation in macrophages during inflammationSemantic proximity Read