Article

<i>LRRK2</i> G2019S mutation suppresses differentiation of Th9 and Treg cells via JAK/STAT3

2024-03-03

Abstract excerpt

The Leucine-rich repeat kinase-2 ( LRRK2 ) G2019S mutation, resulting in aberrantly enhanced kinase activity, is one of the well-recognized genetic risk factors in Parkinson’s Disease (PD). Increased LRRK2 activity was also observed in immune cells from PD patients. Emerging results have also unveiled an upsurge in α-synuclein (α-syn)-specific CD4 + T cell responses in PD patients. Given that LRRK2 mutations in...

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Literature Corpus work: 23c0d5d2-a039-593e-920b-9f74c1a02ad9
DOI: 10.1101/2024.02.28.582561

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