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Article

Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo.

Brain : a journal of neurology - 1 Jun 2018

Kozina Elena, Sadasivan Shankar, Jiao Yun, Dou Yuchen, Ma Zhijun, Tan Haiyan, Kodali Kiran, Shaw Timothy, Peng Junmin, Smeyne Richard J

Abstract excerpt

Missense mutations in the leucine rich repeat kinase 2 (LRRK2) gene result in late-onset Parkinson's disease. The incomplete penetrance of LRRK2 mutations in humans and LRRK2 murine models of Parkinson's disease suggests that the disease may result from a complex interplay of genetic predispositions and persistent exogenous insults. Since neuroinflammation is commonly associated with the pathogenesis of...

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Identifiers

PMID: 29800472
DOI: 10.1093/brain/awy077
PMCID: PMC7190032

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