The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells.

doi:10.1016/j.stem.2009.12.009

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells.

Cell stem cell - 5 Feb 2010

Heng Jian-Chien Dominic, Feng Bo, Han Jianyong, Jiang Jianming, Kraus Petra, Ng Jia-Hui, Orlov Yuriy L, Huss Mikael, Yang Lin, Lufkin Thomas, Lim Bing, Ng Huck-Hui

Abstract excerpt

Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) with the introduction of Oct4, Sox2, Klf4, and c-Myc. Among these four factors, Oct4 is critical in inducing pluripotency because no transcription factor can substitute for Oct4, whereas Sox2, Klf4, and c-Myc can be replaced by other factors. Here we show that the orphan nuclear receptor Nr5a2 (also known as Lrh-1) can replace Oct4 in the...

Topics

Animals
Base Sequence
Cells, Cultured
Cellular Reprogramming
Epigenesis, Genetic
Gene Expression Profiling
Genome-Wide Association Study
Humans
Induced Pluripotent Stem Cells
Kruppel-Like Factor 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kruppel-Like Transcription Factors

Mice

Mutation

Octamer Transcription Factor-3

Protein Binding

Receptors, Cytoplasmic and Nuclear

SOXB1 Transcription Factors

SUMO-1 Protein

Source

Open in PubMed

Identifiers

PMID: 20096661
DOI: 10.1016/j.stem.2009.12.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells.PMID 20096661Read ↗

NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression.Semantic proximity Read ↗

NCOR1 and OCT4 Facilitate Early Reprogramming by Co-Suppressing Fibroblast Gene ExpressionSemantic proximity Read ↗

Nr5a2 promotes cancer stem cell properties and tumorigenesis in nonsmall cell lung cancer by regulating NanogSemantic proximity Read ↗

Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4Semantic proximity Read ↗

Reconstitution of pluripotency from mouse fibroblast through Sall4 overexpressionSemantic proximity Read ↗

Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming.Semantic proximity Read ↗

Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells.Semantic proximity Read ↗

Direct reprogramming of mouse fibroblasts to neural progenitorsSemantic proximity Read ↗

Concise Review: Pursuing Self-Renewal and Pluripotency with the Stem Cell Factor NanogSemantic proximity Read ↗

RCOR2 Is a Subunit of the LSD1 Complex That Regulates ESC Property and Substitutes for SOX2 in Reprogramming Somatic Cells to PluripotencySemantic proximity Read ↗

A Member of the Nuclear Receptor Superfamily, Designated as NR2F2, Supports the Self‐Renewal Capacity and Pluripotency of Human Bone Marrow‐Derived Mesenchymal Stem CellsSemantic proximity Read ↗

Coordination of Multiple Cellular Processes by NR5A1/Nr5a1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.