Article
The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells.
Cell stem cell - 5 Feb 2010
Heng Jian-Chien Dominic, Feng Bo, Han Jianyong, Jiang Jianming, Kraus Petra, Ng Jia-Hui, Orlov Yuriy L, Huss Mikael, Yang Lin, Lufkin Thomas, Lim Bing, Ng Huck-Hui
Abstract excerpt
Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) with the introduction of Oct4, Sox2, Klf4, and c-Myc. Among these four factors, Oct4 is critical in inducing pluripotency because no transcription factor can substitute for Oct4, whereas Sox2, Klf4, and c-Myc can be replaced by other factors. Here we show that the orphan nuclear receptor Nr5a2 (also known as Lrh-1) can replace Oct4 in the...
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