Article

Development of an in vitro cerebral ischemia model of the blood-brain barrier based on human induced pluripotent stem cells: The pivotal role of microenvironmental cells

2025-07-08

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> During cerebral insults, such as traumatic brain injury (TBI) and ischemic stroke, flow cessation leads to cerebral ischemia and this in turn to the breakdown of the blood-brain barrier (BBB) which worsens patient survival rate and recovery outcome. Several <italic>in vitro</italic> models exist simulating cerebral ischemia applying oxygen/glucose deprivation (O...

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Literature Corpus work: cfcdcca1-deb3-53aa-a8b5-5d4bd82e8664
DOI: 10.21203/rs.3.rs-6513614/v1

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