Article

Pericytes and Wnt signaling induce functional blood-brain barrier phenotype in human iPSC-based model

2025-09-26

Abstract excerpt

The blood-brain barrier (BBB), formed by brain microvascular endothelial cells (BMECs), restricts vascular permeability through tight junctions, selective transporters, and low transcytosis. BBB dysfunction contributes to cerebrovascular and neurodegenerative disease, yet current human in vitro models recapitulate only a subset of BMEC features. Here, we describe a strategy generate BMECs (hiBMECs) from human indu...

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Literature Corpus work: 241440e0-3895-5282-b55d-51df0c2bd4c1
DOI: 10.1101/2025.09.26.678752

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