Article

High and low permeability of human pluripotent stem cell-derived Blood Brain barrier models depend on epithelial or endothelial features

2022-06-01

Abstract excerpt

<h4>SUMMARY</h4> The search for reliable human blood-brain barrier (BBB) models represents a challenge for the development/testing of strategies aiming to enhance brain delivery of drugs. Human induced pluripotent stem cells (hiPSCs) have raised hopes in the development of predictive BBB models. Differentiating strategies are thus required to generate endothelial cells (ECs), a major component of the BBB. Several...

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Literature Corpus work: b8d258d0-5dc7-55fb-b9ca-a27894ffe893
DOI: 10.1101/2022.05.31.494120

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