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The presence of BBB hastens neuronal differentiation of cerebral organoids – the potential role of endothelial derived BDNF

2022-07-22

Abstract excerpt

Despite remaining the best in vitro model to resemble the human brain, a weakness of human cerebral organoids is the lack of the endothelial component that in vivo organizes in the blood brain barrier (BBB). Since the BBB is crucial to control the microenvironment of the nervous system, this study proposes a co-culture BBB and cerebral organoids. We utilized a BBB model consisting of primary brain microvascular en...

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Literature Corpus work
99028541-c12a-54f1-aa46-ce9f11532e13
DOI
10.1101/2022.07.22.501119
Open publication

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The presence of BBB hastens neuronal differentiation of cerebral organoids – the potential role of endothelial derived BDNFDOI 10.1101/2022.07.22.501119
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