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A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria

1 May 2024

Abstract excerpt

BACKGROUND: Blood-brain barrier (BBB) disruption is a central feature of cerebral malaria (CM), a severe complication of Plasmodium falciparum (Pf) infections. In CM, sequestration of Pf-infected red blood cells (Pf-iRBCs) to brain endothelial cells combined with inflammation, hemolysis, microvasculature obstruction and endothelial dysfunction mediates BBB disruption, resulting in severe neurologic symptoms...

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PMID: 38693577
DOI: 10.1186/s12987-024-00541-9

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