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Prolonged Culturing of IPSC-derived Brain Endothelial-like Cells Is Associated With Quiescence, Downregulation of Glycolysis, and Resistance to Disruption by an Alzheimer’s Brain Milieu

2021-10-21

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Human induced pluripotent stem cell (hiPSC)-derived brain endothelial-like cells (iBECs) are a robust, scalable, and translatable model of the human blood-brain barrier (BBB). Prior works have shown that high transendothelial electrical resistance (TEER) persists in iBECs for at least two weeks, emphasizing the utility of the model for longer term studies. Howev...

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Literature Corpus work
e67343a3-5144-58d0-b4ee-42b872380437
DOI
10.21203/rs.3.rs-968596/v1
Open publication

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Prolonged Culturing of IPSC-derived Brain Endothelial-like Cells Is Associated With Quiescence, Downregulation of Glycolysis, and Resistance to Disruption by an Alzheimer’s Brain MilieuDOI 10.21203/rs.3.rs-968596/v1
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