Article

ARF suppresses 5’-terminal oligopyrimidine mRNA translation

2020-02-09

Abstract excerpt

Tumor cells require nominal increases in protein synthesis in order to maintain high proliferation rates. As such, tumor cells must acquire enhanced ribosome production. How many of the mutations in tumor cells ultimately achieve this aberrant production is largely unknown. The gene encoding ARF is the most commonly deleted gene in human cancer. ARF plays a significant role in regulating ribosomal RNA synthesis an...

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Literature Corpus work: cfcb602a-e8a7-5831-9695-ba4b598bd292
DOI: 10.1101/2020.02.07.939165

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