Article
Mutant KRAS-driven selective mRNA translation reveals mechanisms and therapeutic vulnerabilities in cancer.
Cell reports - 23 Jun 2026
Shrivastava Ankita, Pederson Eric Nels, Nguyen Trang Uyen, Chuen Jacky, Mohan Prathibha, Pande Shivangi, Toribio Ana Ruiz, Lecomte Nicolas, Melchor Jerry, McAuliffe John C, Grandgenett Paul M, Rajasekhar Vinagolu K, Nishikawa Kaila, Knörlein Anna, David Yael, Willis Ian M, Iacobuzio-Donahue Christine A, Ouyang Zhengqing, Singh Kamini
Abstract excerpt
Mutant KRAS-driven control of protein synthesis remains poorly defined. Here, we define KRAS-dependent translational programs and their acute remodeling upon KRAS inhibition. We find that mutant KRAS controls the translation of a subset of mRNAs and affects the production of proteins of the mRNA translation apparatus. Interestingly, these specific subsets of mRNAs have short, weakly folded 5'UTRs and harbor low...
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